Avis
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Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP). Shield-1 reverses the instability by binding to mutated FKBP.
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Shield-1 stabilizes mtFKBP-fused proteins by binding to FKBP-12 with high affinity, enabling conditional protein expression.
Shield-1 is a protein stabilizing ligand that prevents the proteosomal degradation of proteins fused to FK-506 binding protein 1A (FKBP12)